Donate to Remove ads

Got a credit card? use our Credit Card & Finance Calculators

Thanks to johnstevens77,Bhoddhisatva,scotia,Anonymous,Cornytiv34, for Donating to support the site

AstraZeneca - Update on the Phase III EAGLE trial of Imfinzi

For discussion of the practicalities of setting up and operating income-portfolios which follow the HYP Group Guidelines. READ Guidelines before posting
Forum rules
Tight HYP discussions only please - OT please discuss in strategies
idpickering
The full Lemon
Posts: 11276
Joined: November 4th, 2016, 5:04 pm
Has thanked: 2468 times
Been thanked: 5761 times

AstraZeneca - Update on the Phase III EAGLE trial of Imfinzi

#185244

Postby idpickering » December 7th, 2018, 7:06 am



Update on the Phase III EAGLE trial of Imfinzi and
tremelimumab in advanced head and neck cancer

AstraZeneca and MedImmune, its global biologics research and development arm, today announced overall survival (OS) results for the Phase III EAGLE trial. EAGLE is a randomised, open-label, multi-centre trial evaluating Imfinzi (durvalumab) monotherapy or Imfinzi in combination with tremelimumab, an anti-CTLA4 antibody, versus standard-of-care (SoC) chemotherapy in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) who experienced disease progression following platinum-based chemotherapy, regardless of their PD-L1 tumour status.


https://www.investegate.co.uk/astrazene ... 00057484J/

daveh
Lemon Quarter
Posts: 2191
Joined: November 4th, 2016, 11:06 am
Has thanked: 409 times
Been thanked: 807 times

Re: AstraZeneca - Update on the Phase III EAGLE trial of Imfinzi

#185262

Postby daveh » December 7th, 2018, 8:55 am

The important bit is:

Imfinzi monotherapy and the combination of Imfinzi plus tremelimumab did not meet the primary endpoints of improving OS compared to SoC chemotherapy in these hard-to-treat patients. The safety and tolerability profiles for Imfinzi and the combination with tremelimumab were consistent with previous experience.


Which is disappointing both for investors and for patients.


Return to “HYP Practical (See Group Guidelines)”

Who is online

Users browsing this forum: Bing [Bot] and 9 guests