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AstraZeneca PLC (AZN)

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Wizard
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Re: AstraZeneca PLC (AZN)

#359760

Postby Wizard » November 24th, 2020, 10:26 pm

Bouleversee wrote:Actually, I think I heard on the lunchtime news that AZN would not be charging certain overseas countries for their vaccine even after the first year. Does anyone have any detail on that? Perhaps he should get Boris to fund that as part of our overseas aid programme.

I heard that AZN will not profit from poorer nations, not give it away for free.

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Re: AstraZeneca PLC (AZN)

#359769

Postby Bouleversee » November 24th, 2020, 10:43 pm

Thanks for clarification, Wizard. So just carry on as the first year. Makes better sense.

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Re: AstraZeneca PLC (AZN)

#359883

Postby Bouleversee » November 25th, 2020, 11:04 am

The Times also mentions today that the half dose was given accidentally. One does wonder how this could happen in a drugs trial. How much confidence can we have that whoever administers the vaccine in the real world (it sounds as though they will be drawn from a wide circle) will give the right treatment for each individual? I think we are quite a long way off being ready to start that ball rolling. The elderly will include many with underlying disease and I get the impression that it is still not known whether the vaccine will be safe for them. The question is not being answered anyway.

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Re: AstraZeneca PLC (AZN)

#359890

Postby Dod101 » November 25th, 2020, 11:17 am

We'd better not start yet another Covid thread but many of the best discoveries seem to happen accidentally (such as penicillin). However I trust that whilst AstraZeneca will no not make a big profit, they surely need to do more than cover their costs. They are after all not a charity and have a lot of very patient investors.

Dod

absolutezero
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Re: AstraZeneca PLC (AZN)

#359987

Postby absolutezero » November 25th, 2020, 3:58 pm

scrumpyjack wrote:
Added to that, in AZN's case, maybe people expected 90%-95% efficacy so when it is announced as 70% efficacy, there is much disappointment

All well and good except that AZN's vaccine IS 90%+ effective.
The "news" has been going on about 70% but read beyond the 'headlie'.

monabri
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Re: AstraZeneca PLC (AZN)

#360162

Postby monabri » November 26th, 2020, 9:01 am


Bouleversee
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Re: AstraZeneca PLC (AZN)

#360163

Postby Bouleversee » November 26th, 2020, 9:08 am

monabri wrote:https://reaction.life/astrazeneca-vaccine-problems-with-the-trials/


Groan! :shock:

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Re: AstraZeneca PLC (AZN)

#360173

Postby Dod101 » November 26th, 2020, 9:34 am

I wonder how reliable that comment is? Could help to explain the share price which is now down to around £77. Anyway that is what the regulator is for so time will tell.

Dod

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Re: AstraZeneca PLC (AZN)

#360175

Postby scrumpyjack » November 26th, 2020, 9:41 am

absolutezero wrote:
scrumpyjack wrote:
Added to that, in AZN's case, maybe people expected 90%-95% efficacy so when it is announced as 70% efficacy, there is much disappointment

All well and good except that AZN's vaccine IS 90%+ effective.
The "news" has been going on about 70% but read beyond the 'headlie'.


Well the 70% is the average between the 62% actual result from the majority vaccinations carried out at the intended dose and the 90% result from a very small sample where a manufacturing error resulted in the first dose being at 50% of the intended level. they don't yet know if the 90% figure for that small sample is statistically significant.

It may all turn out well in the end, but it is not surprising the market is disappointed at this stage after the Pfizer results

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Re: AstraZeneca PLC (AZN)

#360177

Postby monabri » November 26th, 2020, 9:45 am

Was it a manufacturing error? Just think if the error administered a much higher dosage by mistake....where was the check? I can see much mileage being made out of these "errors" .

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Re: AstraZeneca PLC (AZN)

#360197

Postby Bouleversee » November 26th, 2020, 10:41 am

Bouleversee wrote:The Times also mentions today that the half dose was given accidentally. One does wonder how this could happen in a drugs trial. How much confidence can we have that whoever administers the vaccine in the real world (it sounds as though they will be drawn from a wide circle) will give the right treatment for each individual? I think we are quite a long way off being ready to start that ball rolling. The elderly will include many with underlying disease and I get the impression that it is still not known whether the vaccine will be safe for them. The question is not being answered anyway.


I was right when I said the above yesterday. The article linked by Monabri doesn't offer all that much clarification either. I assume the dosage mistake was in Brazil and although the one and a half dose was 90% effective it wasn't given to anyone over 55 so the likelihood of its being used for the first in line for vaccinations in this country is distinctly remote. No numbers given in the article for the double dose trial and it doesn't actually state in that article whether it was given to the elderly but I think it has been stated elsewhere that it was. However, 62% effective is not exactly appealing; the failiures may have been the elderly. Still no mention of those with underlying disease.

I think it was a big mistake to make any announcement until further, more comprehensive trials had been conducted. It just leads to confusion. Very disappointing from both a medical and an investment p.o.v.

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Re: AstraZeneca PLC (AZN)

#360206

Postby monabri » November 26th, 2020, 10:59 am

https://www.investorschronicle.co.uk/co ... nksgiving/


"Serendipitous it may have been, but the charge is that Astra has not been entirely forthcoming with the data. Moreover, the head of the US ‘Operation Warp Speed’ programme, Moncef Slaoui, said yesterday that the more effective dose was only administered to people aged under 55. Worth noting that he used to work for Moderna until very recently. The criticism seems to be coming largely from across the pond, but shares have taken bit of a hit since Monday – it may be difficult for Astra to get emergency approval in the US. Pfizer and Moderna would not be too unhappy about that. "

I wonder how many shares he has in Moderna?

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Re: AstraZeneca PLC (AZN)

#360208

Postby Bouleversee » November 26th, 2020, 11:00 am

However, AZN are trying to be positive:

https://www.dailymail.co.uk/news/articl ... -flag.html

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Re: AstraZeneca PLC (AZN)

#360476

Postby monabri » November 27th, 2020, 12:00 am

AZN need to go forward on the following basis, I would suggest!

Split the vaccine into 2 variants.

1.administer the half dose/full dose variant to all people below age 55.
2.administer the full-full dose to over 55 to 65 age group.

This still leaves the UK government the Pfizer and Moderna vaccines to administrator to other groups as desired.

This buys AZN time to do repeat tests.

Unbelievably, the dosing error was pointed out to AZN in July ...they should have started the repeat trials then.

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Re: AstraZeneca PLC (AZN)

#360564

Postby tjh290633 » November 27th, 2020, 11:43 am

monabri wrote:AZN need to go forward on the following basis, I would suggest!

Split the vaccine into 2 variants.

1.administer the half dose/full dose variant to all people below age 55.
2.administer the full-full dose to over 55 to 65 age group.

This still leaves the UK government the Pfizer and Moderna vaccines to administrator to other groups as desired.

This buys AZN time to do repeat tests.

Unbelievably, the dosing error was pointed out to AZN in July ...they should have started the repeat trials then.

Why? That surely defeats the object of the exercise, which is to show that the half/full dose regime works for all age groups.

And do they do it just in the UK or in all the other trials going on?

From the RNS: https://www.investegate.co.uk/astrazene ... 00071391G/

The pooled analysis included data from the COV002 Phase II/III trial in the UK and COV003 Phase III trial in Brazil. Over 23,000 participants are being assessed following two doses of either a half-dose/full-dose regimen or a regimen of two full doses of AZD1222 or a comparator, meningococcal conjugate vaccine called MenACWY or saline. The global trials are evaluating participants aged 18 years or over from diverse racial and geographic groups who are healthy or have stable underlying medical conditions.

Clinical trials are also being conducted in the US, Japan, Russia, South Africa, Kenya and Latin America with planned trials in other European and Asian countries. In total, the Company expects to enrol up to 60,000 participants globally.


TJH

Bouleversee
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Re: AstraZeneca PLC (AZN)

#360574

Postby Bouleversee » November 27th, 2020, 11:56 am

But they don't yet know how effective or safe the one and a half dose regime is on the over 55s do they? Those results were based on trials of under 55s so we'll have to wait a bit longer for further info.

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Re: AstraZeneca PLC (AZN)

#360593

Postby monabri » November 27th, 2020, 12:22 pm

tjh290633 wrote:[

Why? That surely defeats the object of the exercise, which is to show that the half/full dose regime works for all age groups.

TJH


It will take time to prove the half/full dose might be the most effective. In the meantime, the UK might have to rely on vaccines from Pfizer and Moderna only and there isn't sufficient availability. So, protect the under 55s ( a high percentage of the population) with available AZN vaccine and use scarcer US vaccines on the group 1, group 2 high risk groups.

Ideally, in x months, AZN will have gathered more trial results. There's no guarantee that the half/full dose is best.

Still, AZN and Oxford are a set of duckeggs especially when they knew mid year that there was a trial problem.

They were given instructions on how to set out the trials and they seem to have deviated and not followed them....double duckeggs!

Dod101
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Re: AstraZeneca PLC (AZN)

#360602

Postby Dod101 » November 27th, 2020, 12:51 pm

This is an investment thread and seeing the mixed messages (to put it mildly) from AstraZeneca it is no wonder that the shares have taken a hit. Their PR is not very good either. They need to get a grip and fast.

Dod

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Re: AstraZeneca PLC (AZN)

#360857

Postby tjh290633 » November 28th, 2020, 12:15 pm

monabri wrote:Still, AZN and Oxford are a set of duckeggs especially when they knew mid year that there was a trial problem.

They were given instructions on how to set out the trials and they seem to have deviated and not followed them....double duckeggs!

Having found that the incorrect vaccination regime was not being followed, they very sensibly decided to continue with that regime to obtain their conclusions. If you look at the RNS it is obvious that there are many trials in progress. What we do not know except by speculation in the press is how the initial lower dose came about. That is immaterial if it is found to give a superior result. The important thing is that a properly conducted trial was carried out to its conclusion and gave the results quoted.

TJH

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Re: AstraZeneca PLC (AZN)

#361798

Postby idpickering » December 1st, 2020, 1:48 pm

Crestor to be divested to Grünenthal in Europe

AstraZeneca has agreed to sell the rights to Crestor ( rosuvastatin) and associated medicines in over 30 countries in Europe, except the UK and Spain, to Grünenthal GmbH (Grünenthal). Crestor is a statin approved for the treatment of dyslipidaemia and hypercholesterolaemia.

Ruud Dobber, Executive Vice President, BioPharmaceuticals Business Unit, said: "This agreement supports the management of our mature medicines to enable reinvestment into the pipeline and bringing new, innovative treatments to patients. Grünenthal previously acquired the rights to several established AstraZeneca medicines and is well placed to ensure continued access to Crestor for patients across Europe."

AstraZeneca will continue to manufacture and supply Crestor to Grünenthal during a transition period. AstraZeneca will also continue selling the medicine in other countries, including those in North America, in Japan, China and other emerging markets.


https://www.investegate.co.uk/astrazene ... 00070728H/


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