Page 1 of 23

GlaxoSmithKline PLC (GSK)

Posted: January 21st, 2019, 7:05 am
by idpickering
GlaxoSmithKline plc (LSE/NYSE: GSK) today announces that Sir Philip Hampton has informed the Board of his intention to step down as non-executive Chairman and the Board has started the process to find a successor.


https://www.investegate.co.uk/glaxosmit ... 00466088N/

GSK Completes Acquisition of Tesaro

Posted: January 22nd, 2019, 2:02 pm
by maximan
https://www.londonstockexchange.com/exc ... K/13943004.

RNS Number : 7937N
GlaxoSmithKline PLC
22 January 2019




Issued: 22 January 2019, London UK - LSE Announcement



GSK completes acquisition of TESARO, an oncology focused biopharmaceutical company





GlaxoSmithKline plc (LSE/NYSE: GSK) today announced that it has successfully completed the acquisition of TESARO, Inc. an oncology-focused company based in Waltham, Massachusetts, for an aggregate cash consideration of approximately $5.1 billion (£4.0 billion). The transaction, which was announced on 3 December 2018, significantly strengthens GSK's pharmaceutical business, accelerating the build of GSK's pipeline and commercial capability in oncology.[url][url][/url][/url]

GlaxoSmithKline Plc (GSK)

Posted: February 5th, 2019, 1:14 pm
by maximan
GSK and Merck KGaA, Darmstadt, Germany announce global alliance to jointly develop and commercialise M7824, a novel immunotherapy with potential in multiple difficult-to-treat cancers
https://www.investegate.co.uk/glaxosmit ... 58321388P/

Re: RNS GSK and Merck global alliance

Posted: February 5th, 2019, 2:22 pm
by moorfield
More temporary good news for big pharma shareholders.

I wonder how this will work in 52 days time. :o :twisted:

Re: GlaxoSmithKline Plc (GSK)

Posted: February 17th, 2019, 9:27 am
by Raptor

Re: GlaxoSmithKline Plc (GSK)

Posted: February 22nd, 2019, 12:05 pm
by idpickering
GSK response to SFO Statement

In reference to the announcement issued by the Serious Fraud Office ("SFO") today, GlaxoSmithKline plc (LSE/NYSE: GSK) is pleased that the SFO have closed their investigation and concluded that no further action is required.


https://www.investegate.co.uk/glaxosmit ... 21488883Q/

Re: GlaxoSmithKline PLC (GSK)

Posted: March 8th, 2019, 7:06 am
by idpickering
ViiV positive ph3 data for long acting injectable

ViiV Healthcare presents positive, 48-week data from two pivotal phase III studies showing long-acting, injectable two-drug regimen of cabotegravir and rilpivirine has similar efficacy to daily, three-drug oral treatment in adults living with HIV-1 infection


https://www.investegate.co.uk/glaxosmit ... 00022408S/

Re: GlaxoSmithKline PLC (GSK)

Posted: March 14th, 2019, 1:28 pm
by idpickering
Is the GSK share price the bargain of the year?

FTSE 100 pharma giant GlaxoSmithKline (LSE: GSK) is heading for a break-up. Chief executive Emma Walmsley will oversee the creation of two companies — a focused and faster-growing pharmaceutical company and a profitable, stable consumer healthcare business.

This strategy isn’t a sure thing, but I think there’s a good chance it will work. Today I’ll explain why. I’ll also take a look a FTSE 250 stock which I think offers an interesting mix of opportunity and risk.

A break-up makes sense


https://www.fool.co.uk/investing/2019/0 ... -the-year/

Glaxo Smith Kline (GSK)

Posted: March 19th, 2019, 5:50 pm
by maximan
RNS Number : 3623T
GlaxoSmithKline PLC
19 March 2019




Issued: 19 March 2019, London UK - LSE Announcement



Data from GARNET study indicates robust activity of dostarlimab in patients with advanced or recurrent endometrial cancer



· GARNET is the single largest study to date of an anti-PD-1 monotherapy in women with advanced or recurrent MSI-H and MSS endometrial cancer

· Results demonstrate clinically meaningful and durable response rates of dostarlimab monotherapy, in MSI-H and MSS tumours

· BLA submission planned for dostarlimab in endometrial cancer at the end of 2019
https://www.investegate.co.uk/glaxosmit ... mab/201903

Re: Glaxo Smith Kline (GSK)

Posted: March 19th, 2019, 6:01 pm
by maximan
Sorry link keeps failing. It is on Investigate if you go direct.

Re: Glaxo Smith Kline (GSK)

Posted: March 19th, 2019, 6:10 pm
by Itsallaguess
maximan wrote:
Sorry link keeps failing. It is on Investigate if you go direct.


This one should work -

https://www.investegate.co.uk/glaxosmit ... 45023623T/

Cheers,

Itsallaguess

Re: GlaxoSmithKline PLC (GSK)

Posted: March 21st, 2019, 4:47 pm
by maximan
GlaxoSmithKline plc (LSE/NYSE: GSK) today announced further positive data from the DREAMM-1 study of patients with relapsed/refractory multiple myeloma who received GSK2857916, an investigational anti-B-cell maturation antigen (BCMA) antibody-drug conjugate. These results, published in Blood Cancer Journal (link) build upon results from the pre-specified interim analysis, which were first presented at the American Society of Haematology Congress in 2017.

https://www.investegate.co.uk/glaxosmit ... 00016374T/

Re: GlaxoSmithKline PLC (GSK)

Posted: April 9th, 2019, 7:05 am
by idpickering
FDA approves ViiV's two-drug HIV regimen, Dovato

ViiV Healthcare today announced that the US Food and Drug Administration (FDA) approved Dovato, a complete, once-daily, single-tablet regimen of dolutegravir (DTG) 50 mg and lamivudine (3TC) 300 mg for the treatment of HIV-1 infection in adults with no antiretroviral (ARV) treatment history and with no known resistance to either DTG or 3TC. Dovato, a two-drug regimen (2DR), reduces exposure to the number of ARVs from the start of treatment, while still maintaining the efficacy and high barrier to resistance of a traditional DTG-based three-drug regimen.1


https://www.investegate.co.uk/glaxosmit ... 00025072V/

Re: GlaxoSmithKline PLC (GSK)

Posted: June 7th, 2019, 7:05 am
by idpickering
FDA approval for Nucala self-administration

GlaxoSmithKline (LSE/NYSE: GSK) today announced that the US Food and Drug Administration (FDA) has approved two new methods for administering Nucala (mepolizumab), an autoinjector and a pre-filled safety syringe, for patients or caregivers to administer once every four weeks, after a healthcare professional decides it is appropriate. This is the first anti-IL5 biologic to be licensed in the US for at-home administration, and the first respiratory biologic to be approved for administration via an autoinjector.


https://www.investegate.co.uk/glaxosmit ... 00024560B/

Re: GlaxoSmithKline PLC (GSK)

Posted: July 10th, 2019, 7:18 am
by idpickering
ViiV switch study shows 2DR as effective as 3DR

ViiV Healthcare announces phase III study meets primary endpoint, demonstrating the ability to control HIV-1 with a 2-drug regimen of dolutegravir plus lamivudine in virally suppressed patients switching from a TAF-containing, 3-drug regimen


https://www.investegate.co.uk/glaxosmit ... 00030093F/

Re: GlaxoSmithKline PLC (GSK)

Posted: July 10th, 2019, 12:28 pm
by daveh
idpickering wrote:ViiV switch study shows 2DR as effective as 3DR

ViiV Healthcare announces phase III study meets primary endpoint, demonstrating the ability to control HIV-1 with a 2-drug regimen of dolutegravir plus lamivudine in virally suppressed patients switching from a TAF-containing, 3-drug regimen


https://www.investegate.co.uk/glaxosmit ... 00030093F/


My question is why would you want to move from 3DR to 2DR regime. Maybe less complicated to take as the two drugs are combined in a single pill (its unclear whether the 3DR regime is a single pill or 3 pills). Possibility of fewer side effects on the 2DR regime. I looked through the RNS to see if there was a reason given why the 2DR regime might be advantageous, but it didn't seem to say. If I have time I'll do a bit of research and see if I can see what advantages there are to the 2DR regime.

Re: GlaxoSmithKline PLC (GSK)

Posted: July 16th, 2019, 11:01 pm
by tjh290633
My broker has sent me a notice of Corporate Action today, regarding the splitting off of the new Joint Venture with Pfizer.

Other than the vote having been passed at the AGM approving this, I have seen nothing else. No RNS of recent date. I have had a look on the GSK website and see nothing there. Have I missed something, or is this in anticipation of an announcement with the Q1 results next week?

TJH

Re: GlaxoSmithKline PLC (GSK)

Posted: July 16th, 2019, 11:54 pm
by PinkDalek
tjh290633 wrote:My broker has sent me a notice of Corporate Action today, regarding the splitting off of the new Joint Venture with Pfizer.

Other than the vote having been passed at the AGM approving this, I have seen nothing else. No RNS of recent date. I have had a look on the GSK website and see nothing there. Have I missed something, or is this in anticipation of an announcement with the Q1 results next week?

TJH


Other than the AGM, the only RNS of detail I recall concerning this is below:

https://www.investegate.co.uk/glaxosmit ... 00039434K/

I can't say I've kept a close eye on this and I'd assumed the listing was some years away in view of the Within 3 years of the closing of the transaction, GSK intends to separate the Joint Venture via a demerger of its equity interest and a listing of GSK Consumer Healthcare on the UK equity market.

Did you broker provide any further background?

Re: GlaxoSmithKline PLC (GSK)

Posted: July 17th, 2019, 9:08 am
by daveh
As I posted else where where all that my broker said was:
Demerger.

Share holders will recieve Consumer Healthcare Joint Venture (CHJV) shares, at a rate to be determined for each Existing GlaxoSmithKline PLC (GSK) share held on the Ex-entitlement Date, which is yet to be determined.
Important Information & Other Key Dates:
On 19th December 2018, GSK and Pfizer entered into an agreement under which, upon closing of the proposed transaction, Pfizer will contribute its consumer healthcare business to GSK's existing consumer healthcare business in return for equity shares in this business. As a result, a newly Demerged Consumer Health Joint Venture will be created in which GSK will have a controlling 68 percent equity interest and Pfizer 32 percent equity interest.

The Demerger received shareholder approval at the General Meeting held on 8th May 2019.



So no real detail at all and like PD I wasn't expecting anything to happen soon if at all.

Re: GlaxoSmithKline PLC (GSK)

Posted: July 17th, 2019, 9:17 am
by tjh290633
That is virtually word for word what my broker (Halifax badged as Lloyds) said.

It may be that the penny has just dropped that they have not mentioned it earlier. Alternatively someone gave them a heads up that the due date had been decided and will be announced.

TJH