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AstraZeneca PLC (AZN)

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idpickering
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Re: AstraZeneca PLC (AZN)

#239074

Postby idpickering » July 25th, 2019, 7:24 am


idpickering
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Re: AstraZeneca PLC (AZN)

#241735

Postby idpickering » August 5th, 2019, 7:04 am

Forxiga label updated in the EU in type-2 diabetes

AstraZeneca today announced that the European Commission has approved an update to the marketing authorisation for Forxiga (dapagliflozin) to include positive cardiovascular (CV) outcomes and renal data from the Phase III DECLARE-TIMI 58 trial in adults with type-2 diabetes (T2D). The trial enrolled a majority of patients with no existing cardiovascular disease.


https://www.investegate.co.uk/astrazene ... 00068660H/

idpickering
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Re: AstraZeneca PLC (AZN)

#242904

Postby idpickering » August 9th, 2019, 7:07 am

Tagrisso significantly improves overall survival

Tagrisso significantly improves overall survival in the Phase III FLAURA trial for 1st-line EGFR-mutated non-small cell lung cancer

Tagrisso is the only medicine demonstrating statistically-significant overall survival benefit in this setting. Also increased the time patients with central nervous
system metastases lived without disease progression

https://www.investegate.co.uk/astrazene ... 00045270I/

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Re: AstraZeneca PLC (AZN)

#244168

Postby feinmann » August 14th, 2019, 9:45 am


idpickering
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Re: AstraZeneca PLC (AZN)

#245637

Postby idpickering » August 20th, 2019, 7:06 am

Farxiga met primary endpoint in landmark Phase III

AstraZeneca today announced positive results from the landmark Phase III DAPA-HF trial which showed that Farxiga (dapagliflozin) met the primary composite endpoint with a statistically-significant and clinically-meaningful reduction of cardiovascular death or the worsening of heart failure (defined as hospitalisation or an urgent heart failure visit), compared to placebo. The trial was conducted in patients with reduced ejection fraction (HFrEF) on standard of care treatment, including those with and without type-2 diabetes


https://www.investegate.co.uk/astrazene ... 00115994J/

idpickering
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Re: AstraZeneca PLC (AZN)

#245913

Postby idpickering » August 21st, 2019, 7:04 am

Update on the Phase III NEPTUNE trial

AstraZeneca today announced final overall survival (OS) results from the Phase III NEPTUNE trial, a randomised, open-label, multi-centre, global trial of Imfinzi (durvalumab) in combination with tremelimumab, an anti-CTLA4 antibody, vs. standard-of-care (SoC) platinum-based chemotherapy in previously-untreated Stage IV (metastatic) non-small cell lung cancer (NSCLC) patients. The trial was performed in an all-comers population, and the primary analysis population was patients with a high tumour mutational burden (TMB). TMB is a measurement of the number of mutations within the genome (DNA) of a tumour, and tumours with high levels of TMB may be more visible to the immune system.1,2


https://www.investegate.co.uk/astrazene ... 00027014J/

daveh
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Re: AstraZeneca PLC (AZN)

#246001

Postby daveh » August 21st, 2019, 12:33 pm

And the OS was not improved by the new treatment versus SoC. They say they will now look in detail at the data and see if there were any sub groups that showed improvements with the new treatment.

idpickering
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Re: AstraZeneca PLC (AZN)

#247400

Postby idpickering » August 28th, 2019, 7:09 am

Fasenra granted US Orphan Drug Designation for eosinophilic oesophagitis; https://www.investegate.co.uk/astrazene ... 05013730K/

Breztri Aerosphere Phase III ETHOS trial met its primary endpoint in chronic obstructive pulmonary disease; https://www.investegate.co.uk/astrazene ... 00043734K/

Ian.

idpickering
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Re: AstraZeneca PLC (AZN)

#247661

Postby idpickering » August 29th, 2019, 7:05 am

Anifrolumab Phase III trial meets primary endpoint; https://www.investegate.co.uk/astrazene ... 00075254K/

idpickering
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Re: AstraZeneca PLC (AZN)

#248596

Postby idpickering » September 2nd, 2019, 7:09 am

Detailed results from Phase III DAPA-HF trial showed Farxiga significantly reduced both the incidence of cardiovascular death and the worsening of heart failure. https://www.investegate.co.uk/astrazene ... 00078027K/

77ss
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Re: AstraZeneca PLC (AZN)

#248785

Postby 77ss » September 2nd, 2019, 8:56 pm

idpickering wrote:Detailed results from Phase III DAPA-HF trial showed Farxiga significantly reduced both the incidence of cardiovascular death and the worsening of heart failure. https://www.investegate.co.uk/astrazene ... 00078027K/



AZN powers on. A big slice of luck here, by all accounts:

Due to heart complications caused by diabetes drugs in the past, regulators forced the drugmaker to conduct a cardiovascular safety study to ensure that Farxiga--which forces the kidney to remove glucose from the blood to and expel it in urine--wasn't dangerous. The trial revealed that not only was Farxiga harmless, it actually improved heart function.


https://www.marketwatch.com/story/astra ... siteid=rss

Dod101
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Re: AstraZeneca PLC (AZN)

#248790

Postby Dod101 » September 2nd, 2019, 9:47 pm

77ss wrote:
idpickering wrote:Detailed results from Phase III DAPA-HF trial showed Farxiga significantly reduced both the incidence of cardiovascular death and the worsening of heart failure. https://www.investegate.co.uk/astrazene ... 00078027K/



AZN powers on. A big slice of luck here, by all accounts:

Due to heart complications caused by diabetes drugs in the past, regulators forced the drugmaker to conduct a cardiovascular safety study to ensure that Farxiga--which forces the kidney to remove glucose from the blood to and expel it in urine--wasn't dangerous. The trial revealed that not only was Farxiga harmless, it actually improved heart function.


https://www.marketwatch.com/story/astra ... siteid=rss


Hooray! Now over £75 per share.

Dod

grimer
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Re: AstraZeneca PLC (AZN)

#249649

Postby grimer » September 5th, 2019, 4:48 pm

Dod101 wrote:
77ss wrote:
idpickering wrote:Detailed results from Phase III DAPA-HF trial showed Farxiga significantly reduced both the incidence of cardiovascular death and the worsening of heart failure. https://www.investegate.co.uk/astrazene ... 00078027K/



AZN powers on. A big slice of luck here, by all accounts:

Due to heart complications caused by diabetes drugs in the past, regulators forced the drugmaker to conduct a cardiovascular safety study to ensure that Farxiga--which forces the kidney to remove glucose from the blood to and expel it in urine--wasn't dangerous. The trial revealed that not only was Farxiga harmless, it actually improved heart function.


https://www.marketwatch.com/story/astra ... siteid=rss


Hooray! Now over £75 per share.

Dod


My stop loss kicked in today at 7299p.

idpickering
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Re: AstraZeneca PLC (AZN)

#249657

Postby idpickering » September 5th, 2019, 5:04 pm

grimer wrote:
My stop loss kicked in today at 7299p.


My first purchase of AZN shares was on 17 Nov 2009, buying at 2732p ps. My average purchase price since then, having topped up and top sliced periodically, but no more, is 4468p ps. I intend holding on to my shares going forward.

Ian.

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Re: AstraZeneca PLC (AZN)

#249705

Postby grimer » September 5th, 2019, 7:27 pm

idpickering wrote:
grimer wrote:
My stop loss kicked in today at 7299p.


My first purchase of AZN shares was on 17 Nov 2009, buying at 2732p ps. My average purchase price since then, having topped up and top sliced periodically, but no more, is 4468p ps. I intend holding on to my shares going forward.

Ian.


I may buy back in if I see an opportunity. They seem a bit pricey, given the dividend cover, etc.

ADrunkenMarcus
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Re: AstraZeneca PLC (AZN)

#249777

Postby ADrunkenMarcus » September 6th, 2019, 8:07 am

A happy holder with a book cost of 1914p. AZN is 6.7% of my folio now.

I did trim in April, but the proceeds went into Mastercard.

Best wishes

Mark.


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